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Aspirin and Breastfeeding Aspirin and Pregnancy

Aspirin is transferred to breast milk and it is estimated that a nursing baby receives about 4-8% of the mother's dose.

Continued exposure to small doses of aspirin may be harmful to babies because aspirin tends to build up in their bodies. Nursing women are advised against aspirin use because of the possible development of Reye's Syndrome in their babies.

Reye's Syndrome is a rare condition that affects the brain and liver and is most often observed in children given aspirin during a viral illness. Because sufficient information is not available to accurately determine the extent of aspirin accumulation in babies and the resulting health outcomes, the World Health Organization Working Group on Human Lactation along with the National Reye's Syndrome Foundation considers aspirin intake by nursing mothers as unsafe.

The American Academy of Pediatrics Committee on Drugs listed aspirin as a drug that has been "associated with significant effects on some nursing infants and should be given to nursing mothers with caution." The report suggested that safer drugs such as acetaminophen should be used for pain relief during pregnancy.


American Academy of Pediatrics. 2001. The Transfer of Drugs and Other Chemicals Into Human Milk Committee on Drugs. Pediatrics 108(3): 776-789.

Findlay JWA, DeAngelis RL, Kearney MF, Welch RM, Findlay JM: Analgesic drugs breast milk and plasma. Clin Pharmacol Ther 29:625-33, 1981.

Iannucci L. The Perplexities of Pregnancy. FDA.

The WHO Working Group, Bennet PN (ed): Drugs and Human Lactation. Elsevier, Amsterdam, New York, Oxford, 1988. pp. 325-6.

The Food and Drug Administration (FDA) has issued the following warning about aspirin use during pregnancy: "It is especially important not to use aspirin during the last three months of pregnancy unless specifically directed to do so by a physician because it may cause problems in the unborn child or complications during delivery."

Aspirin is listed on the California Environmental Protection Agency (CAL/EPA) Proposition 65 list of developmental toxicants (CAL/EPA Proposition 65 List).

A developmental toxicant is a substance that a group of expert scientists has determined can harm unborn children. The FDA warning is included in the CAL/EPA listing.

Drugs may pose dangers to the embryo or fetus throughout pregnancy, but they are especially of concern during the first trimester, when the vital organs and systems are developing, and the last trimester, when excessive bleeding can occur during labor.

According to the New England Journal of Medicine, an estimated 10 to 45 percent of pregnant women in the first trimester, unaware of their condition, reach for the most common OTC drug, aspirin. Aspirin and other drugs containing salicylate are not recommended throughout pregnancy, especially during the last three months, except under a doctor's supervision. Acetylsalicylate, a common ingredient in many OTC painkillers, may prolong pregnancy and cause excessive bleeding before and after delivery.

Android Apps & eBooks The NRSF Blog School and Health Department Packages - Free! Talking to Tweens and Teens About Aspirin and Other Medications Join the Effort to Eradicate Reye's
We've created an App for the Android phone and tablets all about Aspirin, from lists of products containing and not containing aspirin, to drug interactions with aspirin, to diseases that aspirin negatively impacts...Learn More Our Blog is a great way to learn even more about aspirin and children, and get tips and hints about a range of things all centered around Reye's Syndrome and aspirin...Learn More The Foundation makes a special Reye's Syndrome Information package available to Schools, Health Departments, Human Resource Divisions, and to anyone who would like Reye's Syndrome information...Learn More Helping themselves, and sharing meds is a serious issue with Tweens and Teens. They do not realize the dangers involved, and often think OTC drugs are harmless. Talk to them about drugs, and Reye's... Learn More Through Awareness and Education, we can drastically lower the number of Reye's Syndrome cases. To do this, we need your help...Learn More


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All Rights Reserved In 1974, the National Reye's Syndrome Foundation, a children's health advocacy organization, was incorporated as a 501(c)3 charity, with a mission to eradicate the incidence of Reye's Syndrome.
The Foundation does not receive, nor seek, government funding, and relies on the generosity of donors for support of all programs. National Reye's Syndrome Foundation 426 N Lewis St. Bryan OH 43506 800.233.7393